Expression of the Heterotrimeric GP2/GP3/GP4 Spike of an Arterivirus in Mammalian Cells
Equine arteritis virus (EAV), an enveloped positive-strand Diecast Truck RNA virus, is an important pathogen of horses and the prototype member of the Arteiviridae family.Unlike many other enveloped viruses, which possess homotrimeric spikes, the spike responsible for cellular tropism in Arteriviruses is a heterotrimer composed of 3 glycoproteins: